New York's venture ecosystem has matured from a fintech-and-media-adjacent afterthought into a genuine rival to Silicon Valley, anchored by firms spanning early-stage specialists to some of the largest growth-equity platforms in the industry, many purpose-built around New York's particular strength in financial services and enterprise software.
New York, NY
Founded 1995
Shopify's 2015 IPO, one of the defining e-commerce software exits of the decade
SoftwareSaaSCybersecurity
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New York, NY
Founded 2001
An early pre-IPO stake in Facebook that helped define Tiger Global's hybrid public-private strategy
InternetFintechConsumer Tech
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New York, NY
Founded 1989
No single confirmed signature exit - OrbiMed is instead widely regarded in biotech as a 'stamp of validation' and IPO accelerator, with many companies specifically seeking its backing to help secure Nasdaq or HKEX listin…
BiotechPharmaceuticalsHealthcareDiagnostics
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New York, NY
Founded 1994
More than $16B (in assets as of December 2025, per the firm's own About page; the figure could not be checked against Form ADV Item 5.F)
Assets Managed
Nuvalent, Inc. (acquired by GSK, completed 15 July 2026, approximately $10.6 billion aggregate equity value)
TherapeuticsMedical DevicesHealthcareDiagnostics
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New York, NY
Founded 1999
Approximately $11B (across its strategies as of 30 June 2026, per the firm's own About page; the firm's Form ADV Item 5.F figure could not be read)
Assets Managed
BiotechLife SciencesMedical DevicesDiagnostics
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New York, NY
Founded 2009
$10B+ (latest fund)
Assets Managed
An early stake in Instagram years before its acquisition by Facebook
Consumer InternetAI
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New York, NY
Founded 1985
Over $10B (under management, stated on the firm's Who We Are page and homepage, checked 2026; Invus Opportunities is separately stated at more than $2B)
Assets Managed
Cava Group (NYSE: CAVA) listed on the New York Stock Exchange on 15 June 2023; Invus states that its affiliate Artal remained Cava's largest shareholder after the offering, so this is a public listing rather than a reali…
ConsumerHealthcareBiotechHospitality
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New York, NY
Founded 2020
dLocal's 2021 NASDAQ IPO under ticker DLO at a $6 billion valuation - Addition's first major public exit, backing the Uruguayan payments company as an early investor
FintechEnterprise SoftwareConsumerAI
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New York, NY
Founded 2000
Auris Health's 2019 acquisition by Johnson & Johnson for up to $6.1 billion - Lux first invested in the surgical robotics company in 2012, seven years before the deal
Deep TechAIHealthcareDefense Tech
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New York, NY
Founded 2015
Accenture's 2025 acquisition of a majority stake in Dragos at a $3.2 billion valuation - EIP partnered with the industrial cybersecurity company in 2017, when the category was still emerging
EnergyClimateGrid TechnologyCybersecurity
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New York, NY
Founded 2008
$3.5B (committed capital)
Assets Managed
Pinterest's 2019 NYSE IPO - Co-Founder Rick Heitzmann personally wrote the company's seed check, years before it went public
Enterprise SoftwareConsumerAIFintech
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New York, NY
Founded 2006
$3B+ (across all funds)
Assets Managed
Venmo - Greycroft was an early seed investor in the payments app; Braintree, which had acquired Venmo, was sold to PayPal for $800 million in 2013
Enterprise SoftwareFintechConsumerAI
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New York, NY
Founded 2015
Ecwid's 2021 acquisition by Lightspeed Commerce for $500 million - PeakSpan invested in the ecommerce platform in March 2020 and exited the following year
AIEnterprise SoftwareVertical SaaSFintech
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New York, NY
Founded 1994
$2.5B+ (across 10 funds)
Assets Managed
Braintree's $800 million acquisition by PayPal in October 2013 - RRE was an early investor in the payments company years before its exit
Enterprise SoftwareFintechConsumerAI
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New York, NY
Founded 2020
$2B (the homepage prints "$2B In assets under management *as of 10/01/2025"; the raw date form is carried here because for a US filer 10/01/2025 reads as 1 October 2025)
Assets Managed
Hyperfine (Nasdaq: HYPR), which became publicly traded through HealthCor Catalio Acquisition Corp. (Nasdaq: HCAQ), the special purpose acquisition company of which Catalio co-founder George Petrocheilos was President; th…
HealthcareBiotechMedical DevicesDiagnostics
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New York, NY
Founded 2010
$1.5B (across nine funds)
Assets Managed
BuzzFeed's SPAC merger in December 2021 at a $1.5 billion valuation - Lerer Hippeau was an early backer of the media company, alongside earlier public listings for Warby Parker and Casper
ConsumerHealthcareFintechEnterprise Software
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New York, NY
Founded 2015
Jet.com's approximately $3.3 billion acquisition by Walmart in September 2016 - Brad Svrluga was an early investor via the firm's predecessor, High Peaks Ventures
FintechConsumerHealthcareEnterprise Software
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New York, NY
Founded 2003
Etsy's 2015 IPO - USV backed the handmade-goods marketplace in 2008 when it looked like a niche bet against Amazon
Consumer InternetFintechCryptoMarketplaces
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New York, NY
Founded 2000
$1B (latest fund, 2023)
Assets Managed
Datadog's 2019 Nasdaq IPO - RTP Global was an early Series A-through-D investor in the observability platform, which priced at $27 per share and had grown to a market capitalization of roughly $93 billion by July 2026
AIEnterprise SoftwareFintechDeveloper Tools
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New York, NY
Founded 2018
$650M (Dragonfly Ventures IV close announced February 2026; no firm-wide AUM figure is published)
Assets Managed
CryptoDeFiBlockchainInfrastructure
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New York, NY
Founded 2014
$575M+ (firm-stated, as of December 31, 2023)
Assets Managed
Compost processor Atlas Organics, an early Closed Loop Ventures investment, was acquired by Generate Capital in a January 2022 majority-stake deal reported as a full exit for its early investors.
Circular EconomySustainabilityClimate
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New York, NY
Founded 2007
$550M (across two new funds, as of October 2025)
Assets Managed
Flatiron Health's $1.9 billion acquisition by Roche in 2018 - BoxGroup was an early investor in the healthcare data company, one of several major exits alongside PillPack, Matterport, and Trello
FintechEnterprise SoftwareConsumerDeep Tech
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New York, NY
Founded 2019
$330M (Inspired III)
Assets Managed
Financial TechnologyHealthcareArtificial IntelligenceWorkforce and Education
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New York, NY
Founded 2016
$300M (Companion Fund II close, 2023)
Assets Managed
No confirmed public exit yet; the firm's notable positions remain private.
HealthcareLife SciencesBiotechAnimal Health
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New York, NY
Founded 2010
$250M (Fund VII, 2025)
Assets Managed
CybersecurityAI InfrastructurePhysical AIDeveloper-First Infrastructure
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New York, NY
Founded 2016
$200M+ (site: "$200M+ AUM Across 3 Funds")
Assets Managed
Seed investment The Athletic was acquired by The New York Times for $550 million in 2022.
ConsumerMediaGaming
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New York, NY
Founded 2020
$175M+ (Fund II + Opportunity Fund)
Assets Managed
No public exit yet - Equal Ventures has focused its $175 million in capital on bringing software into legacy industries like insurance, climate, and supply chain
ClimateInsuranceRetailSupply Chain
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New York, NY
Founded 2013
$160M+ (Fund III)
Assets Managed
Oort's acquisition by Cisco - one of several strategic exits in 645's portfolio, alongside LeagueApps' acquisition by Accel-KKR
FintechEnterpriseHealthtechCybersecurity
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New York, NY
Founded 2009
$160M+ (Fund VI)
Assets Managed
No public portfolio exit yet - Eniac has focused exclusively on seed-stage investing since 2009
TechnologySoftwareRoboticsSaaS
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New York, NY
Founded 2013
$160M+ (latest fund)
Assets Managed
CoreOS's acquisition by Red Hat - one of several enterprise infrastructure exits in Work-Bench's portfolio, alongside Semmle's acquisition by GitHub
Enterprise SoftwareAI/MLDeveloper ToolsInfrastructure
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Not publicly disclosed (no AUM figure is published; a $145M second crypto fund was formed in 2022, per the Lowenstein Sandler announcement of 12 May 2022)
Assets Managed
CryptoWeb3BlockchainInfrastructure
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New York, NY
Founded 2015
$134M+ (Fund II)
Assets Managed
No public exit yet - Harlem Capital has grown from a Harlem living-room angel syndicate into a $134 million institutional seed fund across two funds
Industry-Agnostic (Enterprise & Consumer Technology)Diverse Founders
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New York, NY
Founded 2014
$100M+ across three investment vehicles
Assets Managed
B2B SoftwareVertical SaaSFintechHealth Tech
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New York, NY
Founded 2015
$100M (MetaProp Ventures III close, 2021)
Assets Managed
Fund I portfolio company Avail, MetaProp's first investment, was acquired by Realtor.com operator Move, Inc. in December 2020.
ProptechConstruction TechEnterprise Software
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New York, NY
Founded 2018
$100M (stated as "$100M ASSETS UNDER MANAGEMENT" on everywhere.vc, 2026)
Assets Managed
Pre-SeedSector-Agnostic
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New York, NY
Founded 2013
Not publicly disclosed (Fund III closed at $70M in 2021; debut fund closed at $33M in 2013)
Assets Managed
VNDLY (acquired by Workday, 2021)
Enterprise SoftwareSaaSMarketplaces
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New York, NY
Founded 2021
Not publicly disclosed (no AUM figure is published; sourced fund sizes only - Archetype I at $55M, Archetype II at $150M, and Archetype III announced 22 September 2025 with over $100M in total capital commitments)
Assets Managed
CryptoBlockchainInfrastructureDeFi
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New York, NY
Founded 2020
$50M, 2025 Fund II close ($30M Fund I, 2022)
Assets Managed
No confirmed public exit yet; the firm's notable positions remain private.
WaterClimateSustainability
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New York, NY
Founded 2025
$30M+ (debut fund)
Assets Managed
No public exit yet - Worldbuild closed its debut fund in 2026 and is still building its earliest cohort, including SF Compute and Browserbase
AI InfrastructureDeveloper ToolsAerospaceEnergy
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New York, NY
Founded 2014
$29M+ (latest fund)
Assets Managed
Rent the Runway's 2021 Nasdaq IPO - Female Founders Fund was an early backer of Jennifer Hyman's marketplace years before its public debut
Digital HealthAI-First Vertical SoftwareBeauty & Personal CareDeep Tech
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New York, NY
Founded 2023
$25.9M (debut fund, closed January 2026)
Assets Managed
No confirmed public exit yet; the firm's notable positions remain private.
BiodiversityClimateDeep Tech
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New York, NY
Founded 2022
$10M+ (latest fund)
Assets Managed
No public exit yet - The Fintech Fund closed its $10 million second fund in September 2024
FintechCryptoDeFi
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New York, NY
Founded 2021
$8M (initial fund, 2021)
Assets Managed
No public exit documented - Not Boring Capital's first investments were fintech and AI startups
FintechAI
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New York, NY
Founded 2012
Over $1 billion (across four institutional funds)
Assets Managed
Portfolio company Rocket Lab became publicly traded on Nasdaq as RKLB through its merger with Vector Acquisition Corporation in August 2021.
SpaceSatellitesDeep Tech
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New York, NY
Founded 2018
$1 Billion in assets under management (firm's April 2022 release)
Assets Managed
Farfetch, which the firm lists among its exits, went public on the NYSE in 2018 and was later taken over by Coupang.
ConsumerEcommerceRetail
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New York, NY
Founded 2011
Not publicly disclosed
Assets Managed
No single defined public exit documented - Valor bridges Silicon Valley and Brazil, investing in cross-border tech companies
FintechConsumer Internet
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New York, NY
Founded 2020
Not publicly disclosed
Assets Managed
No public equity exit documented - Variant invests in foundational crypto protocols, including an early stake in Uniswap
CryptoDeFi
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New York, NY
Founded 2016
Not publicly disclosed
Assets Managed
Artificial IntelligenceFintechBiotechDefense Tech
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New York, NY
Founded 2018
Portfolio company Standard Nuclear, the Oak Ridge TRISO nuclear fuel maker, completed its initial public offering on the NYSE as STDN in July 2026.
Defense TechNational SecurityEnergyAerospace
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New York, NY
Founded 2005
Datadog (IPO)
Financial TechnologyEnterprise SoftwareSaaSVertical SaaS
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